Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Presence of N-Methylmetadrenaline in Human Urine and Tumour Tissue of Phæochromocytoma

Abstract

IN 1960, Axelrod1 found N-methyladrenaline in adrenal glands of several animals and a large quantity of N-methylmetadrenaline in the urine from the rat administered with N-methyladrenaline. On these findings a new metabolic pathway of adrenaline involving its N-methylation was suggested. The possibility of this new pathway of adrenaline in human beings has been investigated.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Axelrod, J., Biochim. Biophys. Acta, 45, 614 (1960).

    Article  CAS  Google Scholar 

  2. Yoshinaga, K., Itoh, C., Sato, T., Ishida, N., and Wada, Y., Nature, 191, 599 (1961).

    Article  ADS  CAS  Google Scholar 

  3. Yoshinaga, E., Itoh, C., Sato, N., Ishida, N., and Wada, Y., Tohoku J. Exp. Med., 74, 105 (1961).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

ITOH, C., YOSHINAGA, K., SATO, T. et al. Presence of N-Methylmetadrenaline in Human Urine and Tumour Tissue of Phæochromocytoma. Nature 193, 477–478 (1962). https://doi.org/10.1038/193477b0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/193477b0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing