Abstract
CONTEMPORARY pharmacological tests state that ‘Metrazol’ (pentamethylene-tetrazole) has no direct effect on the myocardium. Conflicting opinions are recorded in the literature1. Goodman and Gilman2 claim that the electrocardiographic changes are due to central nervous system influences, an opinion shared by Bircher et al.3. Since the direct role of ‘Metrazol’ on the heart did not seem to be settled, we undertook the following experiments.
Similar content being viewed by others
Article PDF
References
Haury, V. G., and Gruber, C. M., J. Pharmacol. and Exp. Therap., 65, 227 (1939). Eichler, O., and Hildebrandt, F., Arch. Exp. Path. u. Pharm., 116, 110 (1926). Stoland, O. O., and Ginsberg, A. M., J. Pharmacol. and Exp. Therap., 60, 396 (1937).
Goodman, L. S., and Gilman, A., The Pharmacological Basis of Therapeutics, second ed. (Macmillan, New York, 1956).
Bircher, R. P., Kanai, T., and Wang, S. C., Fed. Proc., 19 (1), 111 (1960).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
GILLEN, H., COVINO, B. Effect of ‘Metrazol’ on the Isolated, Perfused Mammalian Heart. Nature 193, 278 (1962). https://doi.org/10.1038/193278a0
Issue Date:
DOI: https://doi.org/10.1038/193278a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.