Abstract
THE investigations of Carlsson1,2, by which he demonstrated that practically all dopamine in the mammalian brain is found in the caudate- and entiform-nucleus (forming an important part of the extrapyramidal system), whereas norepinephrine is present in only minimum quantities, suggest that the function of dopamine is not merely that of a precursor of norepinephrine. Carlsson showed, moreover, that reserpine depletes the dopamine from the corpus striatum and produces a Parkinsonian syndrome which could be counteracted by dopa, the precursor of dopamine.
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References
Carlsson, A., Science, 127, 471 (1958).
Carlsson, A., Pharmacol. Revs., 11, 490 (1959).
de Jong, H., and Baruk, H., La catatonie Experimentale (Masson, Paris, 1930).
Schaltenbrand, G., Pflügers Archiv., 209, 623 (1925).
von Schroeder, W., Arch. Exp. Path. u. Pharm., 17, 125 (1883).
Axelrod, J., Science, 126, 400 (1957).
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ERNST, A. Phenomena of the Hypokinetic Rigid Type caused by O-methylation of Dopamine in the Para-position. Nature 193, 178–179 (1962). https://doi.org/10.1038/193178b0
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DOI: https://doi.org/10.1038/193178b0
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