Zinc Content of Expressed Human Prostatic Fluid


Bertrand and Vladesco1 were the first to show the remarkably high concentration of zinc in the human prostate. The figures obtained by them were 0.49 and 0.53 mgm./gm. dry weight. Mawson and Fischer2 found the average zinc concentration in 7 normal human prostates to be 0.859 mgm./gm. dry weight. Hoare et al.3 found an average of 0.744 mgm./gm. dry weight in 19 normal human prostates. Higher zinc-levels have been reported in human spermatozoa (1.998 mgm./gm. dry weight)4, in human seminal plasma (3.1 mgm./gm. dry weight)5, and in 3 specimens of human carcinoid tissue (av. 1.702 mgm./gm. dry weight)6 (Table 1).

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  1. 1

    Bertrand, G., and Vladesco, R., C.R. Acad. Sci., Paris, 173, 176 (1921).

    CAS  Google Scholar 

  2. 2

    Mawson, C. A., and Fischer, M. I., Canad. J. Med. Sci., 30, 336 (1952).

    CAS  Google Scholar 

  3. 3

    Hoare, R., Delory, G. E., and Penner, D. W., Cancer, 9, 721 (1956).

    CAS  Article  Google Scholar 

  4. 4

    Mawson, C. A., and Fischer, M. I., Biochem. J., 55, 696 (1953).

    CAS  Article  Google Scholar 

  5. 5

    Mawson, C. A., and Fischer, M. I., Nature, 177, 190 (1956).

    ADS  CAS  Article  Google Scholar 

  6. 6

    Feyrter, F., Deutsch. med. Wochschr., 81, 1073 (1956).

    CAS  Article  Google Scholar 

  7. 7

    Daniel, O., Haddad, F., Prout, G., and Whitmore, jun., W. F., Brit. J. Urol., 28, 271 (1956).

    CAS  Article  Google Scholar 

  8. 8

    Mager, M., McNary, jun., W. F., and Lionetti, F., J. Histochem. and Cytochem., 1, 493 (1953).

    CAS  Article  Google Scholar 

  9. 9

    Voigt, G. E., Acta Pathol. Microbiol. Scand., 42, 242 (1958).

    CAS  Article  Google Scholar 

  10. 10

    Rixon, R. H., and Whitfield, J. F., J. Histochem. and Cytochem., 7, 262 (1959).

    CAS  Article  Google Scholar 

  11. 11

    Hall, T., in Trace Analysis, edit. by Yoe and Koch, Chap. 17 (John Wiley and Sons, Inc., 1957).

    Google Scholar 

  12. 12

    Hall, T., unpublished results.

  13. 13

    Weitzel, G., Fretzdorff, A.-M., and Eberhagen, A., Hoppe-Seyler's Z. physiol. Chem., 292, 221 (1953).

    CAS  Article  Google Scholar 

  14. 14

    Weitzel, G., Strecker, F.-J., Roester, U., Buddecke, E., and Fretzdorff, A.-M., Hoppe-Seyler's Z. physiol. Chem., 296, 19 (1954).

    CAS  Article  Google Scholar 

  15. 15

    Weitzel, G., Buddecke, E., Fretzdorff, A.-M., Strecker, F.-J., and Roester, U., Hoppe-Seyler's Z. physiol. Chem., 304, 1 (1956).

    CAS  Article  Google Scholar 

  16. 16

    Fujii, T., J. Fac. Sci. Univ. Tokyo, 7, 313 (1955).

    Google Scholar 

  17. 17

    Fujii, T., Utida, S., and Mizuno, T., Nature, 176, 1068 (1955).

    ADS  CAS  Article  Google Scholar 

  18. 18

    Mizuno, T., J. Fac. Sci., Univ. Tokyo, 7, 477 (1956).

    CAS  Google Scholar 

  19. 19

    Lutz, R. E., J. Ind. Hyg., 8, 177 (1926).

    CAS  Google Scholar 

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MACKENZIE, A., HALL, T. & WHITMORE, W. Zinc Content of Expressed Human Prostatic Fluid. Nature 193, 72–73 (1962). https://doi.org/10.1038/193072a0

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