Letter | Published:

Absorption and Excretion of Penicillin injected into the Muscles of Patients with Diabetes Mellitus

Nature volume 192, pages 987988 (09 December 1961) | Download Citation

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Abstract

THE observation that two patients with sub-acute bacterial endocarditis due to alpha-streptococci highly sensitive to penicillin in vitro failed to respond to administration of six million units of the drug a day led to investigations which revealed low peak blood-levels and abnormal urinary excretion of the antibiotic in both. When the dose of penicillin was increased to a quantity greatly in excess of that suggested by the test-tube sensitivity of the organisms, favourable clinical response followed promptly. Other than the endocarditis, the only finding common to both individuals was the presence of diabetes mellitus. Since a review of published information concerning the pharmacology of penicillin1–4 revealed no data indicating any abnormalities related to the diabetic state, it was decided to investigate this problem.

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References

  1. 1.

    , and , Proc. Soc. Exp. Biol. and Med., 71, 639 (1949).

  2. 2.

    , , and , Amer. J. Med., 5, 202 (1948).

  3. 3.

    , , and , J. Bact., 57, 119 (1948).

  4. 4.

    , , and , Amer. J. Med. Sci., 219. 617 (1950).

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Affiliations

  1. Department of Medicine, Tufts University School of Medicine.

    • L. WEINSTEIN
  2. New England Center Hospital, Boston, Massachusetts.

    • R. H. MEADE

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DOI

https://doi.org/10.1038/192987a0

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