Acrolein and Mengo-Semliki Virus Immunity

Abstract

A PREVIOUS report¹ and unpublished qualitative immunochemical findings indicated that acrolein combines with various serum proteins without altering species characteristics. During this work the antiseptic qualities of acrolein were evident by the absence of growth of microscopic organisms; no growth was demonstrable at any time in any of the sealed acroleinized preparations that had been stored at room temperature during a ten-year period. This is of special interest since strict sterile precautions were not exercised during collection of any of the animal sera. These observations, and the known toxic effects of acrolein, suggested application in the preparation of vaccines.