Letter | Published:

Response of the Reticulo-Endothelial System to Stimulation with Œstrogens

Naturevolume 192pages978979 (1961) | Download Citation



WE have previously shown that diethylstilbœstrol and tri-p-anisylchloroethylene are strong stimulants of the reticulo-endothelial system1. We have also found that when the reticulo-endothelial system is stimulated by diethylstilbœstrol the body defence is raised, as indicated by increased phagocytic activity, elevation of the serum γ-globulin to about three times the normal level, increased antibody formation, and the protection of mice and guinea pigs against lethal doses of virulent bacteria. In previous experiments it was found that the minimum dose of diethylstilbœstrol required to stimulate the reticulo-endothelial phagocytes is about a hundred times greater than that necessary to induce œstrus2 and that after treatment with 0.5 mgm. diethylstilbœstrol daily for 6 days the phagocytic activity returns to normal about 8 days later3.

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  1. 1

    Nicol, T., Bilbey, D. L. J., and Druce, C. G., Nature, 190, 418 (1961).

  2. 2

    Nicol, T., and Ware, C. C., Nature, 185, 42 (1960).

  3. 3

    Ware, C. C., and Nicol, T., Nature, 186, 974 (1960).

  4. 4

    Biozzi, G., Benacerraf, B., and Halpern, B. N., Brit. J. Exp. Path., 34, 441 (1953).

  5. 5

    See Bilbey, D. L. J., and Nicol, T., Nature, 182, 674 (1958).

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  1. Department of Anatomy, King's College, London, W.C.2

    • T. NICOL
    • , D. L. J. BILBEY
    •  & C. DRUCE


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