Letter | Published:

Response of the Reticulo-Endothelial System to Stimulation with Œstrogens

Nature volume 192, pages 978979 (09 December 1961) | Download Citation



WE have previously shown that diethylstilbœstrol and tri-p-anisylchloroethylene are strong stimulants of the reticulo-endothelial system1. We have also found that when the reticulo-endothelial system is stimulated by diethylstilbœstrol the body defence is raised, as indicated by increased phagocytic activity, elevation of the serum γ-globulin to about three times the normal level, increased antibody formation, and the protection of mice and guinea pigs against lethal doses of virulent bacteria. In previous experiments it was found that the minimum dose of diethylstilbœstrol required to stimulate the reticulo-endothelial phagocytes is about a hundred times greater than that necessary to induce œstrus2 and that after treatment with 0.5 mgm. diethylstilbœstrol daily for 6 days the phagocytic activity returns to normal about 8 days later3.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1.

    , , and , Nature, 190, 418 (1961).

  2. 2.

    , and , Nature, 185, 42 (1960).

  3. 3.

    , and , Nature, 186, 974 (1960).

  4. 4.

    , , and , Brit. J. Exp. Path., 34, 441 (1953).

  5. 5.

    See , and , Nature, 182, 674 (1958).

Download references

Author information


  1. Department of Anatomy, King's College, London, W.C.2.

    • T. NICOL
    • , D. L. J. BILBEY
    •  & C. DRUCE


  1. Search for T. NICOL in:

  2. Search for D. L. J. BILBEY in:

  3. Search for J. CORDINGLEY in:

  4. Search for C. DRUCE in:

About this article

Publication history




Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.