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Particle-bound and Free Catecholamines in Dog Hearts and the Uptake of Injected Norepinephrine

Naturevolume 192page978 (1961) | Download Citation



SUBMICROSCOPIC structures containing catecholamines have been found by high-speed centrifugation of homogenates or pressed juice of adrenal medulla1–3, splenic nerves4–6 and brain7. A granular fraction containing catecholamines has been isolated from the pressed juice of cyclostome hearts8. It was the purpose of this investigation to see whether also in mammalian hearts the catecholamines are stored in a particle-bound state; the question was also examined whether injected norepinephrine is taken up by sub-microscopic cell elements. This is of interest since Raab and Gigee9 reported a specific avidity of the heart muscle to absorb and store catecholamines.

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    Blaschko, H., and Welch, A. D., Arch. Exp. Path. Pharmakol., 219, 17 (1953).

  2. 2

    Carlsson, A., and Hillarp, N.-Å., Acta Physiol Scand., 44, 163 (1958).

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    Hillarp, N. Å., Acta Physiol. Scand., 47, 271 (1958).

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    von Euler, U. S., and Hillarp, N.-Å., Nature, 177, 44 (1955).

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    von Euler, U. S., Acta Physiol. Scand., 43, 155 (1958).

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    Schumann, H. J., Arch. Exp. Path. Pharmakol., 234, 17 (1958).

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    Bertler, Å., Hillarp, N. Å., and Rosengren, E., Acta Physiol. Scand., 50, 113 (1960).

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    Östlund, E., Bloom, G., Adams-Ray, J., Ritzén, M., Siegman, M., Nordenstam, H., Lishajko, F., and von Euler, U. S., Nature, 188, 324 (1960).

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    Raab, W., and Gigee, A. B., Circul. Res., 3, 553 (1955).

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    Von Euler, U. S., and Lishajko, F., Acta Physiol. Scand., 45, 122 (1959).

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  1. Department of Medicine, Wayne State University, Detroit

    • A. WEGMANN
    •  & K. KAKO


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