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Particle-bound and Free Catecholamines in Dog Hearts and the Uptake of Injected Norepinephrine

Nature volume 192, page 978 (09 December 1961) | Download Citation

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Abstract

SUBMICROSCOPIC structures containing catecholamines have been found by high-speed centrifugation of homogenates or pressed juice of adrenal medulla1–3, splenic nerves4–6 and brain7. A granular fraction containing catecholamines has been isolated from the pressed juice of cyclostome hearts8. It was the purpose of this investigation to see whether also in mammalian hearts the catecholamines are stored in a particle-bound state; the question was also examined whether injected norepinephrine is taken up by sub-microscopic cell elements. This is of interest since Raab and Gigee9 reported a specific avidity of the heart muscle to absorb and store catecholamines.

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Affiliations

  1. Department of Medicine, Wayne State University, Detroit.

    • A. WEGMANN
    •  & K. KAKO

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https://doi.org/10.1038/192978a0

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