Abstract
THE amino-acid composition of bovine growth hormone has been determined1 by Levy's method2. This procedure, which involves paper chromatography of dinitrophenyl derivatives of amino-acids, is subject to certain limitations such as variable recoveries of tyrosine and lack of resolution of the leucine derivatives. The development of automated ion-exchange chromatography of amino-acids3 has prompted a re-investigation of the amino-acid composition of this protein.
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References
Li, C. H., and Chung, D., J. Biol. Chem., 218, 33 (1956).
Levy, A. L., Nature, 174, 126 (1954).
Spackman, D. H., Stein, W. H., and Moore, S., Anal. Chem., 30, 1190 (1958).
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Léonis, J., and Li, C. H., Biochim. Biophys. Acta, 28, 520 (1958).
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PARCELLS, A. Determination of the Amino-Acid Composition of Bovine Growth Hormone. Nature 192, 971–972 (1961). https://doi.org/10.1038/192971a0
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DOI: https://doi.org/10.1038/192971a0
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