Letter | Published:

Inactivation of Rous Virus by Phospholipase A

Naturevolume 192page896 (1961) | Download Citation



ROUS virus is known to consist of protein, ribonucleic acid (RNA) and lipid, about 40 per cent of which is in the form of phospholipids1,2. Partially purified preparations of the virus are inactivated by a wide range of lipid solvents—organic solvents, bile salts and synthetic detergents—and the loss of infectivity is associated with the shedding from the virus particles of protein-like material3.

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  1. 1

    Claude, A., J. Exp. Med., 61, 41 (1935).

  2. 2

    Bather, R., Brit. J. Cancer, 11, 611 (1957).

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    Drayton, H. A., Brit. J. Cancer, 15 (2), 348 (1961).

  4. 4

    Anderson, S. G., and Ada, G. L., Nature, 188, 876 (1960).

  5. 5

    Carr, J. G., and Harris, R. J. C., Brit. J. Cancer, 5, 83 (1951).

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    Bather, R., Brit. J. Cancer, 7, 492 (1953).

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  1. British Empire Cancer Campaign Unit, Agricultural Research Council, Poultry Research Centre, West Mains Road, Edinburgh, 9

    • H. A. DRAYTON


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