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Nature of Increased Protein and DNA in Chronic Hepatic Injury

Naturevolume 192pages886887 (1961) | Download Citation



EXCESS protein and deoxyribonucleic acid (DNA) are found in chronic hepatic injury, for example, after administration of ethionine1–3, butter yellow4,5, 2 acetyl aminofluorene6,7, and a high fat–low choline–low protein diet1. This suggested that the excess protein or DNA is an abnormal product of the hepatocytes1–3. This is supported by the incorporation of ethionine into hepatic, proteins2, presumably the abnormal proteins. These proteins, or DNA, have been related to cancer1,7. This communication is to point out that the excess protein formation results from alterations in cell population, rather than from formation of abnormal proteins.

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  1. 1

    Farish, P. T., Salmon, W. D., and Sauberlich, H. E., Nutrition, 73, 23 (1961).

  2. 2

    Stekol, J. A., Mody, U., and Perry, F., J. Biol. Chem., 235, 59 (1960).

  3. 3

    Levine, M., and Fopeano, jun., J. V., J. Biol. Chem., 202, 597 (1953).

  4. 4

    Price, J. M., Miller, E. C., and Miller, J. A., J. Biol. Chem., 173, 345 (1948).

  5. 5

    Miller, E. C., and Miller, J. A., J. Nat. Cancer Inst., Supp., 15, 1571 (1955).

  6. 6

    Laird, A. K., and Miller, E. C., Cancer Res., Supp. 1, 13, 464 (1953).

  7. 7

    Rutman, R. J., Cantarow, A., and Paschkis, K. E., Cancer Res., 14, 111 (1954).

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  1. Department of Pathology, Mount Sinai Hospital, Fifth Avenue, New York, 29, N.Y.

    • , ELEMER Cs. GALL
    •  & HANS POPPER


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