Abstract
MICE given intraperitoneal injections of antigen–adjuvant mixture1–3 produce large amounts of ascitic fluid which contains specific antibodies. Inbred AKR mice injected intraperitoneally with isologous tumour cell fragments in modified Freund's adjuvant developed large amounts of peritoneal fluid which contained specific cytotoxic and neutralizing antibodies2,4. These observations had immediate practical importance since immunological studies have been limited by the small amount of antiserum obtainable from each mouse. Since little or no information on the biophysical properties of mouse ascitic fluid is available, an investigation was made of its electrophoretic and immunological characteristics.
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JORDAN, R., BANOVITZ, J., TRAPANI, I. et al. Identification of Antibody in β2-Globulins of Mouse Serum and Ascitic Fluid. Nature 192, 885–886 (1961). https://doi.org/10.1038/192885a0
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DOI: https://doi.org/10.1038/192885a0
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