Letter | Published:

Identification of Antibody in β2-Globulins of Mouse Serum and Ascitic Fluid

Naturevolume 192pages885886 (1961) | Download Citation



MICE given intraperitoneal injections of antigen–adjuvant mixture1–3 produce large amounts of ascitic fluid which contains specific antibodies. Inbred AKR mice injected intraperitoneally with isologous tumour cell fragments in modified Freund's adjuvant developed large amounts of peritoneal fluid which contained specific cytotoxic and neutralizing antibodies2,4. These observations had immediate practical importance since immunological studies have been limited by the small amount of antiserum obtainable from each mouse. Since little or no information on the biophysical properties of mouse ascitic fluid is available, an investigation was made of its electrophoretic and immunological characteristics.

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  1. 1

    Munoz, J., Proc. Soc. Exp. Biol. and Med., 95, 757 (1957).

  2. 2

    Jordan, R. T., Proc. Amer. Assoc. Cancer Res., 3, 31 (1959).

  3. 3

    Lieberman, R., J. Immunol., 84, 514 (1960).

  4. 4

    Jordan, R. T., Current Concepts in Leukemia, Ross Pediatric Res. Conf., 34, 41 (1960).

  5. 5

    Farr, R. S., Campbell, Dan H., and Vinograd, J., Fed. Proc., 13, 492 (1954).

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  1. Department of Experimental Immunology, National Jewish Hospital at Denver, Colorado

    • R. T. JORDAN
    • , J. BANOVITZ
    • , I. L. TRAPANI
    •  & DAN H. CAMPBELL
  2. Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California

    • R. T. JORDAN
    • , J. BANOVITZ
    • , I. L. TRAPANI
    •  & DAN H. CAMPBELL


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