Abstract
ACETYLCHOLINE contracts the spleen of the dog1 and cat2. In these species the effect of acetylcholine in contracting the spleen is not blocked by atropine, but is blocked by dibenzyline and reduced by prior treatment of the animal with reserpine; thus it appears that the action of acetylcholine may be mediated by releasing noradrenaline from its stores in the spleen, which afterwards causes a contraction. The work reported here provides further evidence that acetylcholine liberates noradrenaline from the cat spleen.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Daly, M. de B., and Scott, M. J., J. Physiol., 156, 246 (1961).
Brandon, K. W., and Rand, M. J., J. Physiol., 157, 18 (1961).
Brown, G. L., and Gillespie, J. S., J. Physiol., 138, 81 (1957).
Pennefather, J. N., and Rand, M. J., J. Physiol., 154, 277 (1961).
Boyd, H., Chang, V., and Rand, M. J., Brit. J. Pharmacol., 15, 525 (1960).
Burn, J. H., and Rand, M. J., J. Physiol., 147, 135 (1959).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
BRANDON, K., BOYD, H. Release of Noradrenaline from the Spleen of the Cat by Acetylcholine. Nature 192, 880–881 (1961). https://doi.org/10.1038/192880a0
Issue Date:
DOI: https://doi.org/10.1038/192880a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
