Letter | Published:

Hypertensive Effects of Bradykinin in Rats

Naturevolume 192pages879880 (1961) | Download Citation



BRADYKININ obtained from ox plasma1 and synthetic bradykinin cause intense vasodilatation in many mammalian species. Intravenous injections of bradykinin lower arterial blood pressure in anæsthetized animals. On a molar basis, bradykinin is only ten times less active than acetylcholine and as active as histamine1. Two crude bradykinin-containing extracts from ox plasma—one prepared by us and the other kindly supplied by Prof. Rocha e Silva—were shown to have the typical depressor action in normal rats, but frequently produced a striking hypertensive effect in rats nephrectomized 16–24 hr. before. These results are similar to those obtained with anephrotensin prepared from rat serum2.

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  1. 1

    Elliott, D. F., Horton, E. W., and Lewis, G. P., J. Physiol., 153, 473 (1960).

  2. 2

    Croxatto, H., and Barnafi, L., Recent Progress in Hormone Research, 16 (Academic Press, New York, 1960).

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  1. Laboratorio de Fisiologia, Facultad de Medicina, Universidad Catolica de Chile

    •  & J. BELMAR


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