Abstract
BRADYKININ obtained from ox plasma1 and synthetic bradykinin cause intense vasodilatation in many mammalian species. Intravenous injections of bradykinin lower arterial blood pressure in anæsthetized animals. On a molar basis, bradykinin is only ten times less active than acetylcholine and as active as histamine1. Two crude bradykinin-containing extracts from ox plasma—one prepared by us and the other kindly supplied by Prof. Rocha e Silva—were shown to have the typical depressor action in normal rats, but frequently produced a striking hypertensive effect in rats nephrectomized 16–24 hr. before. These results are similar to those obtained with anephrotensin prepared from rat serum2.
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References
Elliott, D. F., Horton, E. W., and Lewis, G. P., J. Physiol., 153, 473 (1960).
Croxatto, H., and Barnafi, L., Recent Progress in Hormone Research, 16 (Academic Press, New York, 1960).
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CROXATTO, H., BELMAR, J. Hypertensive Effects of Bradykinin in Rats. Nature 192, 879–880 (1961). https://doi.org/10.1038/192879a0
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DOI: https://doi.org/10.1038/192879a0
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