Letter | Published:

Hypertensive Effects of Bradykinin in Rats

Nature volume 192, pages 879880 (02 December 1961) | Download Citation

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Abstract

BRADYKININ obtained from ox plasma1 and synthetic bradykinin cause intense vasodilatation in many mammalian species. Intravenous injections of bradykinin lower arterial blood pressure in anæsthetized animals. On a molar basis, bradykinin is only ten times less active than acetylcholine and as active as histamine1. Two crude bradykinin-containing extracts from ox plasma—one prepared by us and the other kindly supplied by Prof. Rocha e Silva—were shown to have the typical depressor action in normal rats, but frequently produced a striking hypertensive effect in rats nephrectomized 16–24 hr. before. These results are similar to those obtained with anephrotensin prepared from rat serum2.

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References

  1. 1.

    , , and , J. Physiol., 153, 473 (1960).

  2. 2.

    , and , Recent Progress in Hormone Research, 16 (Academic Press, New York, 1960).

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Affiliations

  1. Laboratorio de Fisiologia, Facultad de Medicina, Universidad Catolica de Chile.

    • H. CROXATTO
    •  & J. BELMAR

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DOI

https://doi.org/10.1038/192879a0

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