Letter | Published:

Formation of Histamine and Histamine-like Substances from Histidine by Quartz Dust

Naturevolume 192pages872873 (1961) | Download Citation



IT has been shown1 that quartz dust is capable of participating in a number of oxidative and hydroxylative reactions. The present communication reports the production of histamine, from the interaction of quartz dust with histidine, and the chromatographic isolation of additional products of this reaction, namely, imidazole–carboxylic acids from the lungs of guinea pigs treated with quartz dust.

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  1. 1

    Marasas, L. W., and Harington, J. S., Nature, 188, 1193 (1960).

  2. 2

    Uspensky et al. (U.S.S.R.), quoted in Deutsch. Med. Wochsch., No. 17, 671 (1957).

  3. 3

    Holtz, P., and Heise, R., Arch. Exp. Path. and Pharmakol., 186, 269 (1937). Holtz, P., Naturwiss., 25, 589 (1937).

  4. 4

    Meister, A., Biochemistry of the Amino Acids, 328–333 (Acad. Press, Inc., New York, 1957).

  5. 5

    Van Thoai, N., et al., Biochim. Biophys. Acta, 15, (1954)

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  1. Pneumoconiosis Research Unit of the South African Council for Scientific and Industrial Research, c/o South African Institute for Medical Research, P.O. Box 1038, Johannesburg

    • L. W. MARASAS


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