Letter | Published:

Polysaccharide Content of the Prolapsed Nucleus Pulposus of the Human Intervertebral Disk

Naturevolume 192page868 (1961) | Download Citation



THE nucleus pulposus of normal human intervertebral disk contains the two acidic mucopolysaccharides, chondroitin sulphate and keratosulphate1–3. During ageing an increase of collagen occurs4 leading to a decreased ratio of mucopolysaccharide to collagen, although the absolute amount of mucopolysaccharide remains constant4.

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  1. 1

    Cardell, S., and Rastgeldi, S., Acta Chem. Scand., 8, 362 (1954).

  2. 2

    Bernardi, G., Happey, F., and Naylor, A., Nature, 180, 1341 (1957).

  3. 3

    Hallen, A., Acta Chem. Scand., 12, 1869 (1958).

  4. 4

    Hirsch, C., Paulson, S., Sylven, B., and Snellman, O., Acta Orthopæd. Scand., 22, 175 (1952).

  5. 5

    Hendry, N. G. C., J. Bone and Joint Surg., 40B, 132 (1958).

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  1. Bradford Institute of Technology and Royal Infirmary, Bradford

    • F. HAPPEY
    • , A. WISEMAN
    •  & A. NAYLOR


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