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Autoradiographic Study of Cell Migration during Histogenesis of Cerebral Cortex in the Mouse


AUTORADIOGRAPHY with thymidine labelled with tritium has proved useful for the study of histogenesis in the mammalian brain1–6. Labelled thymidine injected into animals becomes incorporated almost exclusively into deoxyribonucleic acid of cells preparing to divide and remains in their nuclei as a permanent label; the radioactivity is diluted to half with each cell division7. When the autoradiographic method is applied to tissues of animals killed serially, one can determine the time and place of origin of cells, their route and rate of migration, and their ultimate fate.

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ANGEVINE, J., SIDMAN, R. Autoradiographic Study of Cell Migration during Histogenesis of Cerebral Cortex in the Mouse. Nature 192, 766–768 (1961).

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