A Non-diuretic Benzothiadiazine with Anti-hypertensive Properties

Abstract

IN recent years the benzothiadiazine diuretics have become the drugs of choice for treating mild to moderate hypertension. Although their anti-hypertensive effect is relatively weak, they are quite non-toxic and are well absorbed orally. The mechanisms by which these agents reduce blood pressure in hypertensive individuals are not known. Some investigators^1,2 have implicated natriuresis as the primary event, whereas others³ have suggested that the concentration of circulating pressor agents is reduced. That benzothiadiazine diuretics do antagonize in vitro intestinal and aortic contractions has already been demonstrated^4,5. Consequently, the possibility exists that these agents directly affect the responsiveness of vascular smooth muscle. It was, therefore, considered of interest to try to dissociate the anti-hypertensive and diuretic actions of these compounds and, further, to intensify the former action while minimizing the latter.