Abstract
CHROMOSOME abnormalities similar to those known in man are now being found in mice1. Identification of the chromosome complement of these mice in cells from bone marrow2 or corneal epithelium3 involved the death of the animals. The advantage in identifying the chromosome complement of living mice is obvious, and the present communication describes techniques to achieve this in new-born and in adult mice, chiefly by the use of primary outgrowths of cells from pieces of tissue cultured in vitro.
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References
- 1
Welshons, W. J., and Russell, L. B., Proc. U.S. Nat. Acad. Sci., 45, 560 (1959). Cattanach, B. M., Genet. Res. Camb., 2, 156 (1961).
- 2
Ford, C. E., and Hamerton, J. L., Stain Tech., 31, 247 (1956).
- 3
Fechheimer, N. S., Nature, 188, 247 (1960).
- 4
Hsu, T. C., and Klatt, O., J. Nat. Cancer Inst., 21, 437 (1958). Rothfels, K. H., and Siminovitch, L., Stain Tech., 33, 73 (1958).
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Affiliations
Division of Experimental Biology, National Institute for Medical Research, Mill Hill, London, N.W.7
- R. G. EDWARDS
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