Letter | Published:

Deiodination of Thyroxine-131I in Tumour-bearing Rats

Naturevolume 192pages13031304 (1961) | Download Citation



IT has been shown that hyperthyroidism induced by the administration of large doses of triiodothyronine increased the radiosensitivity of tumours in rats and in human beings1,2. Later it was found that hyperthyroidism induced in this way significantly enhances the growth of a solid non-metastatic myeloid leukæmia tumour of the Sprague–Dawley rat, a rat fibrosarcoma of a local strain and the Ehrlich mouse ascites tumour3.

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  1. 1

    Stein, J. A., and Griem, M. L., Nature, 182, 1681 (1958).

  2. 2

    Griem, M. L., and Stein, J. A., Amer. J. Rentgenol. Rad. Nucl. Med., 84, 695 (1960).

  3. 3

    Stein, J. A., and Wiener, E., Block, M., Back, A., and Griem, M. L., Cancer Res. (in the press).

  4. 4

    Clark, O. E., Moe, R. H., and Adams, E. E., Surgery, 26, 331 (1949).

  5. 5

    Corey, K. R., and Gross, J., Cancer Res., 20, 470 (1960).

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Author information


  1. The Hebrew University Hadassa Medical School, Jerusalem

    • J. A. STEIN
    • , M. ANBAR
    • , S. GUTTMANN
    •  & N. ERNST
  2. The Isotope Department, Weizmann Institute of Science, Rehovoth

    • J. A. STEIN
    • , M. ANBAR
    • , S. GUTTMANN
    •  & N. ERNST
  3. Research Laboratories of the Israel Atomic Energy Commission, Rehovoth

    • J. A. STEIN
    • , M. ANBAR
    • , S. GUTTMANN
    •  & N. ERNST


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