Abstract
IT has been shown that hyperthyroidism induced by the administration of large doses of triiodothyronine increased the radiosensitivity of tumours in rats and in human beings1,2. Later it was found that hyperthyroidism induced in this way significantly enhances the growth of a solid non-metastatic myeloid leukæmia tumour of the Sprague–Dawley rat, a rat fibrosarcoma of a local strain and the Ehrlich mouse ascites tumour3.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Stein, J. A., and Griem, M. L., Nature, 182, 1681 (1958).
Griem, M. L., and Stein, J. A., Amer. J. Rentgenol. Rad. Nucl. Med., 84, 695 (1960).
Stein, J. A., and Wiener, E., Block, M., Back, A., and Griem, M. L., Cancer Res. (in the press).
Clark, O. E., Moe, R. H., and Adams, E. E., Surgery, 26, 331 (1949).
Corey, K. R., and Gross, J., Cancer Res., 20, 470 (1960).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
STEIN, J., ANBAR, M., GUTTMANN, S. et al. Deiodination of Thyroxine-131I in Tumour-bearing Rats. Nature 192, 1303–1304 (1961). https://doi.org/10.1038/1921303b0
Issue Date:
DOI: https://doi.org/10.1038/1921303b0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.