Letter | Published:

A Carcinogenic Action of Testosterone, provoking Uterine Tumours in Mice

Nature volume 192, page 1303 (30 December 1961) | Download Citation

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Abstract

THE literature concerning the induction of tumours by hormones is very extensive1–4. Œstrogens especially appeared to play an important part in hormonal carcinogenesis5. Evidence of a carcinogenic action of androgens is very scant. Horning6 observed 3 theca-cell ovarian tumours in rats and 2 adrenal cortical tumours in hamsters after long-term treatment with testosterone. Also, Kirkman7 suggested that testosterone propionate may act as a non-specific carcinogen in the hamster.

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References

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    , Adv. Cancer Res., 1, 173 (1953).

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    , and , Brit. Med. Bull., 14, 106 (1958).

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    , , and , in The Physiopathology of Cancer, second ed., edited by Hamburger, F., and Fishman, W. H., 152 (Hoeber, New York, 1959).

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    , and , Oestrogens and Neoplasia (Blackwell Scientific Publications, Oxford, 1952).

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    , Brit. J. Cancer, 12, 414 (1958).

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    , Acta Un. Int. Cancer, 16, 143 (1960).

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Author information

Affiliations

  1. Laboratory Antoni van Leeuwenhoek-huis, Netherlands Cancer Institute, Amsterdam.

    • R. VAN NIE
    • , E. L. BENEDETTI
    •  & O. MÜHLBOCK

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https://doi.org/10.1038/1921303a0

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