Letter | Published:

Quantitative Aspects of the Re-utilization of Protein-bound Amino-acids in vivo

Nature volume 192, pages 12921293 (30 December 1961) | Download Citation

Subjects

Abstract

THE extent of the re-utilization of protein-bound amino-acids in the formation of new protein has been a subject of interest for many years1–3. The main difficulty with some of the work reported in the literature has been that the half-life of the protein into which the re-utilized amino-acid residue was traced was short. Thus, when one injects a labelled soluble protein and determines the uptake of the label into liver or serum proteins (the half-lives of which are a few days in extent) one deals with a situation in which the uptake, transfer and loss of label is rapid and, furthermore, where the ‘recipient’ protein continually recirculates some of the amino-acid to itself. In these circumstances one is unable to assess reliably the significance or extent of the re-utilization.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    , , , and , Biochem. J., 62, 143 (1956).

  2. 2.

    , and , J. Biol. Chem., 219, 151 (1956).

  3. 3.

    , , , , , , and , J. Biol. Chem., 224, 107 (1957).

  4. 4.

    , and , J. Gen. Physiol., 13, 469 (1930).

  5. 5.

    , Nature, 174, 126 (1954). , and , J. Amer. Chem. Soc., 77, 2899 (1955).

  6. 6.

    , Nature, 167, 513 (1951).

  7. 7.

    Griffith, jun., J. Q., and Farris, E. J. (eds.), The Rat in Laboratory Investigation, 355 (J. B. Lippincott, Philadelphia, 1942).

  8. 8.

    , , and , Nature, 184, 643 (1959).

  9. 9.

    Spector, W. S. (ed.), Handbook of Biological Data, 90 (W. B. Saunders, Philadelphia, 1956).

  10. 10.

    , Adv. Clin. Chem., 1, 237 (1958).

  11. 11.

    , Chemistry and Biology of Proteins, 207 (Academic Press, New York, 1950).

Download references

Author information

Affiliations

  1. Radioisotope Service, Veterans Administration Hospital, Brooklyn, New York.

    • H. WALTER
    •  & H. ZIPPER

Authors

  1. Search for H. WALTER in:

  2. Search for H. ZIPPER in:

About this article

Publication history

Published

DOI

https://doi.org/10.1038/1921292a0

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.