Letter | Published:

Apparent Induction of Malignant Tumours by Organ-Specific Antiserum

Naturevolume 192pages12011202 (1961) | Download Citation



IT was reported1 that rats injected with 3′-methyl-4-dimethylaminoazobenzene (3′-DAB) showed firm binding of this hepatocarcinogen to the structural lipo-protein complex forming the cytoskeleton, that is, endoplasmic reticulum of the liver cell. The binding here in terms of protein nitrogen was higher than elsewhere. It was shown similarly that firm binding occurred in a sub-microsomal fraction shown by Vogt2 to contain all, or nearly all, the tissue-specific antigens in the liver cell. This fraction contained the bulk of the phosphatide in the microsomes and was therefore thought to be derived from the endoplasmic reticulum. As with the structural lipo-protein, binding was higher here than in any other cell fraction.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Westrop, P. W., and Green, H. N., Nature, 186, 350 (1960).

  2. 2

    Vogt, P., Nature, 182, 1807 (1958).

  3. 3

    Price, B. M., Ph.D. thesis, University of London (1961).

  4. 4

    Green, H. N., Acta Unio Intern. contra Cancrum, 17, 215 (1961).

Download references

Author information


  1. Department of Experimental Pathology and Cancer Research, University of Leeds, and Cancer Research Unit, University of Sheffield

    • H. N. GREEN


  1. Search for H. N. GREEN in:

About this article

Publication history

Issue Date



Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.