Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Apparent Induction of Malignant Tumours by Organ-Specific Antiserum

Abstract

IT was reported1 that rats injected with 3′-methyl-4-dimethylaminoazobenzene (3′-DAB) showed firm binding of this hepatocarcinogen to the structural lipo-protein complex forming the cytoskeleton, that is, endoplasmic reticulum of the liver cell. The binding here in terms of protein nitrogen was higher than elsewhere. It was shown similarly that firm binding occurred in a sub-microsomal fraction shown by Vogt2 to contain all, or nearly all, the tissue-specific antigens in the liver cell. This fraction contained the bulk of the phosphatide in the microsomes and was therefore thought to be derived from the endoplasmic reticulum. As with the structural lipo-protein, binding was higher here than in any other cell fraction.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Westrop, P. W., and Green, H. N., Nature, 186, 350 (1960).

    Article  ADS  CAS  Google Scholar 

  2. Vogt, P., Nature, 182, 1807 (1958).

    Article  ADS  CAS  Google Scholar 

  3. Price, B. M., Ph.D. thesis, University of London (1961).

  4. Green, H. N., Acta Unio Intern. contra Cancrum, 17, 215 (1961).

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

GREEN, H. Apparent Induction of Malignant Tumours by Organ-Specific Antiserum. Nature 192, 1201–1202 (1961). https://doi.org/10.1038/1921201b0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/1921201b0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing