Letter | Published:

A Correlation between Surface Charge and Coagulant Action of Phospholipids

Nature volume 192, pages 11971198 (23 December 1961) | Download Citation

Subjects

Abstract

THE property of water-insoluble amphipathic molecules to alter the electrokinetic charge of lipids has been exploited by Bangham and Dawson1 in elucidating the charge requirements of certain enzyme/substrate interactions. Their results show clearly the interdependence of both sign—positive or negative— and magnitude of enzyme and substrate interaction in any particular ionic environment. Whereas variation of pH, uni- or di-valent ion concentrations may affect the charge on both enzyme and substrate simultaneously, the addition of a water-insoluble amphipathic molecule to the lipid ensured an alteration of the substrate exclusively.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    , and , Biochem. J., 72, 486 (1959).

  2. 2.

    , , and , Quart. J. Exp. Physiol., 40, 276 (1955).

  3. 3.

    , and , Quart. J. Exp. Physiol., 41, 31 (1956).

  4. 4.

    , J. Clin. Path., 9, 47 (1956).

  5. 5.

    , , , and , Nature, 182, 642 (1958).

  6. 6.

    , and , Nature, 174, 880 (1954).

Download references

Author information

Affiliations

  1. Institute of Animal Physiology, Agricultural Research Council, Babraham, Cambridge.

    • A. D. BANGHAM

Authors

  1. Search for A. D. BANGHAM in:

About this article

Publication history

Published

DOI

https://doi.org/10.1038/1921197a0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.