Letter | Published:

A Correlation between Surface Charge and Coagulant Action of Phospholipids

Naturevolume 192pages11971198 (1961) | Download Citation



THE property of water-insoluble amphipathic molecules to alter the electrokinetic charge of lipids has been exploited by Bangham and Dawson1 in elucidating the charge requirements of certain enzyme/substrate interactions. Their results show clearly the interdependence of both sign—positive or negative— and magnitude of enzyme and substrate interaction in any particular ionic environment. Whereas variation of pH, uni- or di-valent ion concentrations may affect the charge on both enzyme and substrate simultaneously, the addition of a water-insoluble amphipathic molecule to the lipid ensured an alteration of the substrate exclusively.

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  1. 1

    Bangham, A. D., and Dawson, R. M. C., Biochem. J., 72, 486 (1959).

  2. 2

    Poole, J. C. F., Robinson, D. S., and Macfarlane, R. G., Quart. J. Exp. Physiol., 40, 276 (1955).

  3. 3

    Poole, J. C. F., and Robinson, D. S., Quart. J. Exp. Physiol., 41, 31 (1956).

  4. 4

    O'Brien, J. R., J. Clin. Path., 9, 47 (1956).

  5. 5

    Bangham, A. D., Flemans, R., Heard, D. H., and Seaman, G. V. F., Nature, 182, 642 (1958).

  6. 6

    Bell, W. N., and Alton, H. G., Nature, 174, 880 (1954).

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  1. Institute of Animal Physiology, Agricultural Research Council, Babraham, Cambridge

    • A. D. BANGHAM


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