Letter | Published:

Biological Spectrum of Some New Tuberculostatic 1,3,4-Oxadiazolones with Special Reference to Cross-Resistance and Rates of Emergence of Resistance

Nature volume 192, page 1195 (23 December 1961) | Download Citation

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Abstract

THE tuberculostatic activity of 5-(4-pyridyl)-1,3,4-oxadiazolone (S 57) has been repeatedly confirmed1–3, and complete cross-resistance with isonicotinic acid hydrazid (isoniazid) in laboratory tests using Mycobacterium tuberculosis is reported by all workers in this field. It was, therefore, a little surprising to find that, whereas isoniazid is practically inactive against human leprosy, but active against rat murine leprosy, S 57 is highly active against both animal and human leprosy4–6.

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Author information

Affiliations

  1. Department of Pharmacology, School of Medicine, University of Bergen, Norway.

    • A. E. WILDER SMITH
  2. Department of Pathology, Cantonal General Hospital, Lucerne, Switzerland.

    • HANS BRODHAGE

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DOI

https://doi.org/10.1038/1921195a0

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