Letter | Published:

Biological Spectrum of Some New Tuberculostatic 1,3,4-Oxadiazolones with Special Reference to Cross-Resistance and Rates of Emergence of Resistance

Naturevolume 192page1195 (1961) | Download Citation



THE tuberculostatic activity of 5-(4-pyridyl)-1,3,4-oxadiazolone (S 57) has been repeatedly confirmed1–3, and complete cross-resistance with isonicotinic acid hydrazid (isoniazid) in laboratory tests using Mycobacterium tuberculosis is reported by all workers in this field. It was, therefore, a little surprising to find that, whereas isoniazid is practically inactive against human leprosy, but active against rat murine leprosy, S 57 is highly active against both animal and human leprosy4–6.

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  1. 1

    Wilder Smith, A. E., Science, 119, 515 (1954).

  2. 2

    Stempel, A., Zelauskas, J., and Aeschlimann, J. A., J. Org. Chem., 20, 412 (1955).

  3. 3

    Kakimoto, S., Krüger-Thiemer, E., and Wempe, E., Arzneimittelforschung, 12, 963 (1960).

  4. 4

    Brodhage, H., Leprosy Rev., 148 (1958).

  5. 5

    Jopling, W. H., and Ridley, D. S., Leprosy Rev., 143 (1958).

  6. 6

    Bréchet, R., and Cochrane, R. G., Leprosy Rev., (1961).

  7. 7

    Wilder Smith, A. E., Arzneimittelforschung (in the press).

  8. 8

    Wilder Smith, A. E., Brodhage, H., and Haukenes, G., Arzneimittelforschung (in the press).

  9. 9

    Matsumoto, K. K., and Grossman, M. I., Proc. Soc. Exp. Biol. and Med., 102, 517 (1959).

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  1. Department of Pharmacology, School of Medicine, University of Bergen, Norway

  2. Department of Pathology, Cantonal General Hospital, Lucerne, Switzerland



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