Letter | Published:

Difference in Metabolism of Labelled Thyroxine between Thyrotropic and Adrenotropic Mouse Pituitary Tumours

Naturevolume 192pages11931194 (1961) | Download Citation



LITTLE is known about the mechanisms within the pituitary which are involved in the control of thyrotropin secretion exerted by circulating thyroid hormone. In the work reported here mouse pituitary tumours were used to examine this problem since each of these several tumour types reflects quite closely the behaviour of its prototype cell in the normal pituitary. The results suggest there may be a special thyrotropin-secreting cell with an unusual pattern of metabolism for thyroxine. Thus, mouse pituitary thyrotropic tumours were found to contain large amounts of labelled 3,5,3′-triiodothyronine (T3*) 4 hr. after injection intraperitoneally of labelled thyroxine (T4*), whereas mouse pituitary adrenotropic tumours and other tissues contained none.

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  1. Departments of Medicine and Biochemistry, Columbia University College of Physicians and Surgeons, New York



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