Letter | Published:

Difference in Metabolism of Labelled Thyroxine between Thyrotropic and Adrenotropic Mouse Pituitary Tumours

Naturevolume 192pages11931194 (1961) | Download Citation

Subjects

Abstract

LITTLE is known about the mechanisms within the pituitary which are involved in the control of thyrotropin secretion exerted by circulating thyroid hormone. In the work reported here mouse pituitary tumours were used to examine this problem since each of these several tumour types reflects quite closely the behaviour of its prototype cell in the normal pituitary. The results suggest there may be a special thyrotropin-secreting cell with an unusual pattern of metabolism for thyroxine. Thus, mouse pituitary thyrotropic tumours were found to contain large amounts of labelled 3,5,3′-triiodothyronine (T3*) 4 hr. after injection intraperitoneally of labelled thyroxine (T4*), whereas mouse pituitary adrenotropic tumours and other tissues contained none.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Furth, J., Burnett, W. T., and Gadsden, E. L., Cancer Res., 13, 298 (1953).

  2. 2

    Werner, S. C., and Grinberg, R., Cancer Res., 21, 522 (1961).

  3. 3

    Block, R. J., Werner, S. C., and Mandl, R. H., Arch. Biochem. Biophys., 73, 9 (1958).

  4. 4

    Roche, J., Michel, R., Jouan, R., and Wolf, W., C.R. Acad. Sci., Paris, 241, 1880 (1955).

  5. 5

    Ezrin, C., and Nicholas, W. C., Endocrinol. Soc. Forty-third Meeting Abs., 28 (1961).

  6. 6

    Volpert, E. M., Grinberg, R., and Werner, S. C. (unpublished results).

  7. 7

    Grinberg, R., Volpert, E. M., and Werner, S. C., Endocrinol. Soc. Forty-third Meeting Abs., 63 (1961).

Download references

Author information

Affiliations

  1. Departments of Medicine and Biochemistry, Columbia University College of Physicians and Surgeons, New York

    • SIDNEY C. WERNER
    • , EUGENE M. VOLPERT
    •  & RAUL GRINBERG

Authors

  1. Search for SIDNEY C. WERNER in:

  2. Search for EUGENE M. VOLPERT in:

  3. Search for RAUL GRINBERG in:

About this article

Publication history

Issue Date

DOI

https://doi.org/10.1038/1921193b0

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.