Letter | Published:

Production of Chromatid Aberrations by Diepoxybutane and an Iron Chelator

Naturevolume 192pages10931094 (1961) | Download Citation



RECENT investigations have shown that chromatid breaks produced by certain radiomimetic agents in combination do not interact to produce reunions1. Specifically, breaks produced by 8-ethoxycaffeine do not form exchanges with those produced by maleic hydrazide, nor do the breaks produced by potassium cyanide and β-propiolactone interact with each other. Conversely, breaks induced by X-rays will interact with those produced by potassium cyanide, β-propiolactone, 8-ethoxycaffeine and maleic hydrazide. The interpretation of these results was stated in terms of differences in the bonds broken by the chemical agents, such differences precluding interaction or rejoining of broken ends of chromosomes.

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    Merz, T., Swanson, C. P., and Cohn, N. S., Science, 133, 703 (1961).

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    Wolff, S., and Luippold, H., Science, 122, 231 (1955).

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    Cohn, N. S., Genetics, 43, 362 (1958).

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    Auerbach, C., Rad. Res., 9, 33 (1958).

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    Oster, I. I., Z. f. Indukt. Abstamm. u Vererb., 89, S, 1 (1958).

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    Revell, S. H., Heredity, 6, Supp., 107 (1953).

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    Kihlman, B. A., J. Biophys. Biochem. Cytol., 5, 479 (1959).

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  1. Ohio University, Athens, Ohio



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