Letter | Published:

A New Potent Analgetic Antagonist

Naturevolume 192page1089 (1961) | Download Citation

Subjects

Abstract

THE discovery of a new potent analgetic with a reduced liability to addiction1 in the benzomorphan series, namely, 2′-hydroxy-5,9-dimethyl-2-phenylethyl-6,7-benzomorphan2 (I), has suggested further work in the series. 2′-Hydxoxy-5,9-dimethyl-2-allyl-6,7-benzomorphan (III) is a potent antagonist of phenazocine, morphine, meperidine, and other analgetic agents. This compound is of special interest in that combinations of phenazocine and III in ratios of 5 : 1 to 100 : 1 retain analgetic activity in animals yet seem to be relatively devoid of physical dependence properties in the monkey in both acute and chronic experiments (biological details of this work will be described elsewhere).

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Fraser, H. F., and Isbell, H., Addendum to Minutes of Twentieth Meeting, Committee on Drug Addiction and Narcotics, January 10–11, 1959 (Nat. Acad. Sci.—Nat. Res. Council).

  2. 2

    May, E. L., and Eddy, N. B., J. Org. Chem., 24, 294 (1959).

  3. 3

    J. Pharmacol. Exp. Therap., 112, 356 (1954).

  4. 4

    Bull. Narcotics, 12 (4), 1 (1960).

Download references

Author information

Affiliations

  1. Smith Kline and French Laboratories, Philadelphia, 1

    • MAXWELL GORDON
    • , JOHN J. LAFFERTY
    •  & DAVID H. TEDESCHI
  2. Laboratory of Chemistry, National Institutes of Health, Bethesda, 14, Maryland

    • NATHAN B. EDDY
    •  & EVERETTE L. MAY

Authors

  1. Search for MAXWELL GORDON in:

  2. Search for JOHN J. LAFFERTY in:

  3. Search for DAVID H. TEDESCHI in:

  4. Search for NATHAN B. EDDY in:

  5. Search for EVERETTE L. MAY in:

About this article

Publication history

Issue Date

DOI

https://doi.org/10.1038/1921089a0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.