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A New Potent Analgetic Antagonist

Nature volume 192, page 1089 (16 December 1961) | Download Citation

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Abstract

THE discovery of a new potent analgetic with a reduced liability to addiction1 in the benzomorphan series, namely, 2′-hydroxy-5,9-dimethyl-2-phenylethyl-6,7-benzomorphan2 (I), has suggested further work in the series. 2′-Hydxoxy-5,9-dimethyl-2-allyl-6,7-benzomorphan (III) is a potent antagonist of phenazocine, morphine, meperidine, and other analgetic agents. This compound is of special interest in that combinations of phenazocine and III in ratios of 5 : 1 to 100 : 1 retain analgetic activity in animals yet seem to be relatively devoid of physical dependence properties in the monkey in both acute and chronic experiments (biological details of this work will be described elsewhere).

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References

  1. 1.

    , and , Addendum to Minutes of Twentieth Meeting, Committee on Drug Addiction and Narcotics, January 10–11, 1959 (Nat. Acad. Sci.—Nat. Res. Council).

  2. 2.

    , and , J. Org. Chem., 24, 294 (1959).

  3. 3.

    J. Pharmacol. Exp. Therap., 112, 356 (1954).

  4. 4.

    Bull. Narcotics, 12 (4), 1 (1960).

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Affiliations

  1. Smith Kline and French Laboratories, Philadelphia 1.

    • MAXWELL GORDON
    • , JOHN J. LAFFERTY
    •  & DAVID H. TEDESCHI
  2. Laboratory of Chemistry, National Institutes of Health, Bethesda 14, Maryland.

    • NATHAN B. EDDY
    •  & EVERETTE L. MAY

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https://doi.org/10.1038/1921089a0

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