Letter | Published:

Mechanism of Nicotinic Action at the Adrenal Medulla: Calcium as a Link in Stimulus-secretion Coupling

Nature volume 192, pages 10871089 (16 December 1961) | Download Citation



IN experiments to probe the mechanism of transmission of sympathetic activity at the adrenal medulla we have found that acetylcholine, which is believed to be the chemical transmitter, evokes catecholamine secretion through some calcium-dependent process. Our evidence, obtained in experiments in cats' adrenal glands perfused in vivo or in vitro with Locke's solution or variations of it, may be summarized as follows.

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  1. 1.

    , and , J. Physiol., 159, 24 (1961); Biochem. Pharmacol., 8, 20 (1961).

  2. 2.

    , and , J. Physiol. (in the press).

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  1. Department of Pharmacology, Albert Einstein College of Medicine, New York 61.

    • W. W. DOUGLAS
    •  & R. P. RUBIN


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