Letter | Published:

Elimination of the Liquid Junction by using Glass Electrodes

Nature volume 192, page 1087 (16 December 1961) | Download Citation

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Abstract

IT is assumed in measuring potential with hydrogen or alkali-sensitive glass electrodes1 that the salt bridge which connects the reference electrode to the solution generates a negligibly small potential at the liquid junction. This is a reasonable assumption so long as the unknown solution contains no colloids, and its ionic strength is approximately that of the buffers used in standardization. Unfortunately these ideal conditions are seldom met in biological systems. The resultant error is often of a serious magnitude, as shown in experiments on pH in colloidal systems2,3.

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References

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    , Nature, 184, 1616 (1959).

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    , , , and , Science, 119, 164 (1950).

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    , , and , Soil Sci. Soc. Amer. Proc., 17.214 (1953).

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    , and , J. Amer. Chem. Soc., 68, 1753 (1946).

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    , Ann. New York Acad. Sci., 92, 341 (1961).

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Author information

Affiliations

  1. Cardio-Pulmonary Laboratory, Mt. Alto V.A. Hospital, and Department of Medicine, Georgetown University, School of Medicine, Washington, D.C.

    • CARL. R. MERRIL

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DOI

https://doi.org/10.1038/1921087a0

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