Letter | Published:

Paradoxical Effect of Phlorizin on Glucose Uptake and Intracellular Accumulation of Amino-Acids in Rat Kidney Slices in vitro

Naturevolume 192pages10851086 (1961) | Download Citation



THE discovery by von Mering1 that phlorizin causes glycosuria in the dog and the observation that phlorizin prevents renal tubular re-absorption of glucose2,3 have evoked considerable interest in this substance as a tool in the investigation of cellular transport mechanisms. Much work with phlorizin has shown this drug to be a potent inhibitor of penetration of hexoses and other sugars in gut preparations4,5, kidney slices6, ascites tumour cells7, and red cells8. Significant alteration of intracellular metabolism has also been noted. This literature has recently been reviewed by Lotspeich9 and Crane10.

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    von Mering, I., Z. klin. Med., 14, 405 (1888).

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    Poulsson, L. T., J. Phys., 69, 411 (1930).

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    Shannon, J. A., Jolliffe, N., and Smith, H. W., Amer. J. Phys., 102, 534 (1932).

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    Wilson, R. H., J. Biol. Chem., 97, 497 (1932).

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    Newey, H. B., Parsons, J., and Smyth, D. H., J. Phys., 148, 83 (1959).

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    Krane, S. M., and Crane, R. K., J. Biol. Chem., 234, 211 (1959).

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    Crane, R. K., Field, R. A., and Cori, C. F., J. Biol. Chem., 224, 649 (1957).

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    Le Fevre, P. G., and Marshall, J. K., J. Biol. Chem., 234, 3022 (1959).

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    Lotspeich, W. D., Metabolic Aspects of Renal Function (Charles C. Thomas, Springfield, Ill., 1959).

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    Crane, R. K., Physiol. Revs., 40, 789 (1960).

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    Rosenberg, L. E., Blair, A., and Segal, S., Biochim. Biophys. Acta (in the press).

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    Battaglia, F. C., Manchester, K. C., and Randle, P., Biochim. Biophys. Acta, 43, 50 (1960).

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    Lambrechts, A., C.R. Soc. Biol., 121, 870 (1956).

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    Lotspeich, W. D., and Keller, D., J. Biol. Chem., 222, 843 (1956).

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    Braun, W., Whittaker, V. P., and Lotspeich, W. D., Amer. J. Physiol., 190, 563 (1957).

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  1. Clinical Endocrinology Branch, National Institute of Arthritis, and Metabolic Diseases and Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland



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