Letter | Published:

A Central Action of 5-Hydroxytryptamine and Noradrenaline

Nature volume 192, pages 10831084 (16 December 1961) | Download Citation

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Abstract

THE experiments reported here were based on the observation that an intra-carotid or intravenous injection of d-lysergic acid diethylamide (LSD-25) depresses the transmission of orthodromic impulses through the lateral geniculate nucleus of the cat1. The nature of this depression suggests that LSD-25 can compete with the excitatory transmitter for post-synaptic receptor sites. Consequently the known antagonism between LSD-25 and 5-hydroxytryptamine (5-HT) at receptors of smooth muscle2 indicates the possibility that the as yet unknown central excitatory transmitter might be related to 5-HT. It is probable that the failure to demonstrate an action of 5-HT on these neurones1 was due to the blood-brain barrier, which is relatively impermeable to this substance3.

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References

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    , Ann. N.Y. Acad. Sci., 66, 479 (1956). , , , and , Trans. Ophthal. Soc. Austral., 20, 50 (1961).

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    , , , and , Quart. J. Exp. Physiol., 40, 49 (1955).

  3. 3.

    , in Hormones, Brain Function and Behaviour, edit. by Hoagland, H. (Academic Press, 1957).

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    , and , J. Physiol., 141, 435 (1958). , and , J. Neurochem., 6, 117 (1960).

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    , , , , , , , and , Helv. Chim. Acta, 42, 1557 (1959).

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Affiliations

  1. Department of Physiology, Australian National University, Canberra.

    • D. R. CURTIS
    •  & R. DAVIS

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https://doi.org/10.1038/1921083a0

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