Letter | Published:

Distribution of Trypsin Inhibitors in the Sera of Various Animals

Naturevolume 192page1077 (1961) | Download Citation



TRYPSIN inhibitors have been found in pancreas, serum, colostrum, egg-white, soya bean, and lima bean1. They have all been crystallized except from egg-white2. Thus, examination of the distribution of trypsin inhibitors in proteins of them appears to be out of the question. Recently, Nakamura et al.3 have demonstrated, by two-dimensional paper electrophoresis, that two trypsin inhibitors were contained in the extract of soya-bean. Hence the distribution of trypsin inhibitors in other biological fluids deserves to be re-investigated to see whether there are also two inhibitors in them or not.

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  1. 1

    Green, N. M., and Neurath, H., in The Proteins, 2, 1060 (Acad. Press Inc., New York, 1950). Laskowski, M., and Laskowski, jun., M., Advances in Protein Chem., 9, 203 (1954).

  2. 2

    Wu, F. C., and Laskowski, M., J. Biol. Chem., 235, 1680 (1960).

  3. 3

    Nakamura, S., Takeo, K., Tanaka, K., and Ueta, T., Z. physiol. Chem., 318, 115 (1960).

  4. 4

    Nakamura, S., Tanaka, K., and Murakawa, S., Nature, 188, 144 (1960).

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  1. Institute for Medical Chemistry, Yamaguchi Medical School, Ube, Japan

    •  & T. WAKEYAMA


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