Letter | Published:

Carcinogenicity of the Methyl-1,2-Benzanthracenes and their Derivatives

Nature volume 192, pages 10701072 (16 December 1961) | Download Citation

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Abstract

A NUMBER of theories have recently been put forward to account for the carcinogenic activity of the polycyclic aromatic hydrocarbons; in their present form, the majority of these theories do not provide a rationale for the fact that a number of chemically dissimilar carcinogens appear to operate through some common protein deletion principle1. Previous descriptions of a possible mechanism of carcinogenesis2–4 have pointed out, however, that, in principle at least, the unifying mechanism by which such carcinogens act may be their formation of charge-transfer complexes with proteins; we are now able to discuss the activities of the methyl-1,2-benzanthracenes and the mono-fluoro-10-methyl-1,2-benzanthracenes (Fig. 1) in such terms.

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Affiliations

  1. Centre de Mécanique Ondulatoire, 155 Rue de Sèvres, Paris, 15, and Department of Chemistry, Imperial College of Science and Technology, London, S.W.7.

    • O. CHALVET
    •  & R. MASON

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https://doi.org/10.1038/1921070a0

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