Letter | Published:

Carcinogenicity of the Methyl-1,2-Benzanthracenes and their Derivatives

Naturevolume 192pages10701072 (1961) | Download Citation



A NUMBER of theories have recently been put forward to account for the carcinogenic activity of the polycyclic aromatic hydrocarbons; in their present form, the majority of these theories do not provide a rationale for the fact that a number of chemically dissimilar carcinogens appear to operate through some common protein deletion principle1. Previous descriptions of a possible mechanism of carcinogenesis2–4 have pointed out, however, that, in principle at least, the unifying mechanism by which such carcinogens act may be their formation of charge-transfer complexes with proteins; we are now able to discuss the activities of the methyl-1,2-benzanthracenes and the mono-fluoro-10-methyl-1,2-benzanthracenes (Fig. 1) in such terms.

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  1. 1

    Heidelberger, C., and Moldenhauer, M. G., Cancer Res., 16, 442 (1956).

  2. 2

    Mason, R., Nature, 181, 820 (1958).

  3. 3

    Mason, R., Brit. J. Cancer, 12, 469 (1958).

  4. 4

    Mason, R., Cahier de Physique, 124, 473 (1960).

  5. 5

    Miller, E. C., and Miller, J. A., Cancer Res., 20, 133 (1960).

  6. 6

    Miller, E. C., and Miller, J. A., Proc. Amer. Assoc. Cancer Res., 3, 134 (1960).

  7. 7

    Davis, K. M. C., Eley, D. D., and Snart, R. S., Nature, 188, 724 (1960).

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  1. Centre de Mécanique Ondulatoire, 155 Rue de Sèvres, Paris, 15

    • O. CHALVET
    •  & R. MASON
  2. Department of Chemistry, Imperial College of Science and Technology, London, S.W.7

    • O. CHALVET
    •  & R. MASON


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