Inhibition by Physostigmine of the Increase of Oxygen Consumption induced by Potassium in Muscle

Abstract

THE immersion of frog muscle in Ringer solution, with a high potassium content, is known to cause a decrease in the resting potential of the fibres accompanied by a large increase in oxygen consumption and heat production of long duration; no mechanical change of muscle is observed in these conditions. A possible cause of this effect was discussed by Hill and Howarth1, and a hypothesis was suggested according to which the depolarization produced by potassium releases the catabolic processes normally accompanying contraction of muscle. Nevertheless, the whole mechanism is still very obscure.

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References

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NOVOTNÝ, I., VYSKOČIL, F. Inhibition by Physostigmine of the Increase of Oxygen Consumption induced by Potassium in Muscle. Nature 191, 916–917 (1961). https://doi.org/10.1038/191916a0

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