Metabolites of Vitamin B12 in Bile after Parenteral Administration of the Vitamin


SEVERAL investigations have shown that, in animals and in man1, the major proportion of the total radioactivity excreted after an injection of radioactive vitamin B12 is excreted in the bile, and that in man at least two-thirds of the biliary radioactivity is re-absorbed from the intestine. This indicates that vitamin B12 is subject to an entero-hepatic circulation similar to other substances in bile.

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STOKES, J. Metabolites of Vitamin B12 in Bile after Parenteral Administration of the Vitamin. Nature 191, 807–808 (1961).

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