Biosynthesis of Polyenoic Fatty Acids in Human Whole Blood

Abstract

IT has been known for some time now that human blood cells are able to incorporate acetate-1-14C into blood lipids1,2. James et al.2,3 found the incorporation of radioactive acetate into the saturated as well as into the unsaturated fatty acids of blood lipids, including the ‘essential fatty acids’. Based on these experiments, the authors concluded that a total synthesis of essential fatty acids in human blood would be possible. Klenk4 and Mead et al.5 showed that the C20- and C22-polyenoic fatty acids in rat liver originate from exogenous linoleic and linolenic acids by extension of the carbon chain by acetate units starting at the carboxylic group. In addition, new double bonds are introduced in the divinylmethanerhythm in direction towards the acid group. This mechanism is valid for polyenoic acid synthesis in the human liver6 as well as in the descending classes of vertebrates7.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Altman, K. I., and Swisher, S. N., Nature, 174, 459 (1954).

  2. 2

    James, A. T., Lovelock, J. E., and Webb, J., Biochem. J., 66, 60 (1957); Essential Fatty Acids, 72 (Butterworth, London, 1958).

  3. 3

    James, A. T., Lovelock, J. E., and Webb, J., Biochem. J., 73, 106 (1959).

  4. 4

    Klenk, E., Z. Physiol. Chem., 302, 268 (1955).

  5. 5

    Mead, J. F., Steinberg, G., and Howton, D. R., J. Biol. Chem., 205, 683 (1953).

  6. 6

    Leupold, F., and Kremer, G., Z. Physiol. Chem., 318, 251 (1960).

  7. 7

    Klenk, E., and Kremer, G., Z. Physiol. Chem., 320, 111 (1960).

  8. 8

    Buchanan, A. A., Biochem. J., 75, 315 (1960).

  9. 9

    Rowe, C. E., Allison, A. C., and Lovelock, J. E., Biochim. Biophys. Acta, 41, 310 (1960).

  10. 10

    Marks, P. A., Gellhorn, A., and Kidson, C., J. Biol. Chem., 235, 2579 (1960).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

LEUPOLD, F., KREMER, G. Biosynthesis of Polyenoic Fatty Acids in Human Whole Blood. Nature 191, 805–806 (1961). https://doi.org/10.1038/191805a0

Download citation

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.