Application of the Nickel Reaction and Thermal Isomerization of Alpha-Keto-Acid Hydrazones for their Chromatographic Analysis

Abstract

THE nickel reaction, discovered by Katsuki et al.1, produces a red colour with pure cis isomers of α-keto-acid-2,4-dinitrophenylhydrazones and differentiates them from their corresponding trans isomers. We have found that this reaction applies to isomeric differentiation of the keto-acid hydrazones on paper chromatograms by the following procedures:

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References

  1. 1

    Katsuki, H., Sumizu, K., Moriwaki, T., Tanaka, S., and Hayashi, I., Nature, 181, 639 (1958).

  2. 2

    Tokushige, A. M., and Cook, E. S., Nature, 184, 267 (1959).

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TOKUSHIGE, A., COOK, E. Application of the Nickel Reaction and Thermal Isomerization of Alpha-Keto-Acid Hydrazones for their Chromatographic Analysis. Nature 191, 797–798 (1961). https://doi.org/10.1038/191797a0

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