Removal of Internally Deposited Radionuclides by Triethylenetetraamine-hexaacetic Acid

Abstract

INCREASING the number of donor groups in chelating agents can give rise to the formation of more stable chelates1–3 and, therefore, to a higher mobilization of internally deposited trivalent and other metal ions of higher valency. This has been demonstrated with ethylenediamine - NNN′N′ - tetraacetic acid (EDTA) and diethylenetriamine-NNN′N′N″-penta-acetic acid (DTPA)4,5, that is, with chelating agents with 6 and 8 donor groups respectively. For this reason extension of this work to the 10-dentate triethylenetetraamine - NNN′ N′ N″ N‴ - hexaacetic acid (TTHA) seemed to be worth while.

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References

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    Anderegg, G., Nägeli, P., Müller, F., and Schwarzenbach, G., Helv. Chim. Acta, 42, 827 (1959).

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    Harder, R., and Chaberek, S., J. Inorg. Nucl. Chem., 11, 197 (1959).

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    Heller, H. J., and Catsch, A., Strahlentherapie, 109, 464 (1959).

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    Catsch, A., Fed. Proc., Supp. 1961 (in the press), which includes further references.

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CATSCH, A., SCHINDEWOLF-JORDAN, D. Removal of Internally Deposited Radionuclides by Triethylenetetraamine-hexaacetic Acid. Nature 191, 715 (1961). https://doi.org/10.1038/191715a0

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