Chemistry of a Mucopolysaccharide produced by Guinea Pig Lymphocytes


THE guinea pig lymphocyte has long been known to contain a special inclusion body. Such lymphocytes, called Kurloff cells after their discoverer, increase greatly in number in pregnancy and were shown by Ledingham1 to be produced in both malesand females by administration of œstrogens. Marshall and Swettenham2, by histochemical methods, have shown that the inclusion body is composed of a mucoprotein–sulphated mucopolysaccharide complex. Further work on the chemistry of a mucopolysaccharide fraction by extraction of spleens of œstrogen-treated guinea pigs gave the following results:

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  1. 1

    Ledingham, J. C. G., J. Path. Bact., 50, 201 (1940).

  2. 2

    Marshall, A. H. E., and Swettenham, K. V., J. Anat., 93, 348 (1959).

  3. 3

    Gardell, S., Acta Chem. Scand., 7, 207 (1953).

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MUIR, H., MARSHALL, A. Chemistry of a Mucopolysaccharide produced by Guinea Pig Lymphocytes. Nature 191, 706 (1961).

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