Prevention of Ammonia Toxicity by Amino-acids concerned in the Biosynthesis of Urea


RELATIONSHIPS have been pointed out by several investigators1 between high levels of blood ammonia and various clinical syndromes, for example, some psychoses, mental disturbances associated with heart failure, tumours, jaundices, hepatic encephalopathies, etc. In some cases a reduction in the level of ammonia has resulted in considerable amelioration of these pathological symptoms; the various procedures for this purpose are of considerable interest1.

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SALVATORE, F., BOCCHINI, V. Prevention of Ammonia Toxicity by Amino-acids concerned in the Biosynthesis of Urea. Nature 191, 705–706 (1961).

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