Immunological Study of experimentally induced Extrahepatic Cholestasis

Abstract

COHEN et al. 1 have shown, by means of an immuno-cyto-chemical-fluorescence method, that gamma-globulin is present in the reticulo-endothelial cells of the sinusoids and fibrous tracts of human livers affected by hepatitis of various types and by post-necrotic cirrhosis. To test, in some measure, the unitary concept of liver disease put forward by Shorter et al. 2, it was decided to investigate whether similar changes occurred in livers damaged experimentally by the primarily extrinsic method of ligation of the common bile duct.

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References

  1. 1

    Cohen, S., Ohta, G., Singer, E. J., and Popper, H., J. Exp. Med., 111, 285 (1960).

  2. 2

    Shorter, R. G., Paton, A., and Pinniger, J. L., Quart. J. Med., 28, 43 (1959).

  3. 3

    Havens, W. P., Internat. Arch. Allergy and App. Immunol. (Basle), 14, 75 (1959).

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SHORTER, R., LACK, R. Immunological Study of experimentally induced Extrahepatic Cholestasis. Nature 191, 610–611 (1961). https://doi.org/10.1038/191610a0

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