Immunological Study of experimentally induced Extrahepatic Cholestasis


COHEN et al. 1 have shown, by means of an immuno-cyto-chemical-fluorescence method, that gamma-globulin is present in the reticulo-endothelial cells of the sinusoids and fibrous tracts of human livers affected by hepatitis of various types and by post-necrotic cirrhosis. To test, in some measure, the unitary concept of liver disease put forward by Shorter et al. 2, it was decided to investigate whether similar changes occurred in livers damaged experimentally by the primarily extrinsic method of ligation of the common bile duct.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Cohen, S., Ohta, G., Singer, E. J., and Popper, H., J. Exp. Med., 111, 285 (1960).

  2. 2

    Shorter, R. G., Paton, A., and Pinniger, J. L., Quart. J. Med., 28, 43 (1959).

  3. 3

    Havens, W. P., Internat. Arch. Allergy and App. Immunol. (Basle), 14, 75 (1959).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

SHORTER, R., LACK, R. Immunological Study of experimentally induced Extrahepatic Cholestasis. Nature 191, 610–611 (1961).

Download citation

Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.